BernheimV1, Main, Exploration, bibRecord, 000220

Basic science in Parkinson’s disease: its impact on clinical practice

Identifieur interne : 000220 ( Main/Exploration ); précédent : 000219; suivant : 000221

Basic science in Parkinson’s disease: its impact on clinical practice

Auteurs : Jörg B. Schulz [Allemagne] ; Manfred Gerlach [Allemagne] ; Gabriele Gille [Allemagne] ; Wilfried Kuhn [Allemagne] ; Martina Müngersdorf [Allemagne] ; Peter Riederer [Allemagne] ; Martin Südmeyer [Allemagne] ; Albert Ludolph [Allemagne]

Source :

Journal of Neurology [ 0340-5354 ] ; 2011-05-01.

RBID : ISTEX:CB8DABEF5DA5653D066CB12A1B793FD3C8066B26

Descripteurs français

Wicri :
- topic : Génétique, Histoire.

English descriptors

KwdEn :
- Basic science, Genetics, History, Parkinson’s disease, Treatment.

Abstract

Abstract: Failures in clinical studies that were aimed to prove disease-modifying effects of treatments in Parkinson’s disease (PD) raise the question as to whether basic sciences have had an impact in clinical practice. This question implies that despite well-publicized results obtained by intensive genetic and pathogenetic research, e.g. the identification of mutations and cellular biochemical pathways that underlie Parkinson-specific neurodegeneration, no relevant disease-modifying treatment options have been developed. This view neglects the fact that today there are plenty of dopaminergic and non-dopaminergic and surgical treatment options, and that PD was not treatable 50 years ago. This progress was made possible only by basic science. In this review, we underline the success of previous basic science for daily practice in PD and its impact for the understanding and development of an early diagnosis. Early, even pre-symptomatic diagnosis might be key to successfully establish disease-modifying treatments.

Url:

https://api.istex.fr/document/CB8DABEF5DA5653D066CB12A1B793FD3C8066B26/fulltext/pdf

DOI: 10.1007/s00415-011-6040-y

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream Main, to step Merge: 000220
to stream Main, to step Curation: 000220

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: Failures in clinical studies that were aimed to prove disease-modifying effects of treatments in Parkinson’s disease (PD) raise the question as to whether basic sciences have had an impact in clinical practice. This question implies that despite well-publicized results obtained by intensive genetic and pathogenetic research, e.g. the identification of mutations and cellular biochemical pathways that underlie Parkinson-specific neurodegeneration, no relevant disease-modifying treatment options have been developed. This view neglects the fact that today there are plenty of dopaminergic and non-dopaminergic and surgical treatment options, and that PD was not treatable 50 years ago. This progress was made possible only by basic science. In this review, we underline the success of previous basic science for daily practice in PD and its impact for the understanding and development of an early diagnosis. Early, even pre-symptomatic diagnosis might be key to successfully establish disease-modifying treatments.</div>
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Serveur d'exploration Hippolyte Bernheim

Basic science in Parkinson’s disease: its impact on clinical practice

Basic science in Parkinson’s disease: its impact on clinical practice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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